1. Diabetic Retinopathy Treatment
2. Yiqi Yangyin Huoxue
3. Traditional Chinese Medicine
4. Vision Improvement
5. Meta-Analysis Research

The Promise of Ancient Wisdom

In a groundbreaking systematic review and meta-analysis, researchers have brought to light the benefits of an age-old treatment derived from the vast repository of Traditional Chinese Medicine (TCM), the Yiqi Yangyin Huoxue (YQYYHX) method, in the fight against diabetic retinopathy (DR). This condition is an escalating concern globally, potentially leading to significant vision impairment among individuals suffering from diabetes. The meta-analysis, bearing the Digital Object Identifier (DOI) 10.1155/2019/6020846, compiles the findings of several randomized controlled trials to evaluate the efficacy of YQYYHX method, and the results spotlight a potential paradigm shift in managing DR.

The Scourge of Diabetic Retinopathy

Diabetic retinopathy, triggered by prolonged periods of high blood sugar levels, is a leading cause of blindness among adults worldwide. This condition arises from damage to the blood vessels of the light-sensitive tissue at the back of the eye (retina) and can result in varying degrees of vision loss and is often asymptomatic until it becomes advanced. Current medical interventions include laser treatment, surgical procedures, and careful diabetes management; however, they often come with considerable risks and side effects, underlining an urgent need for alternative therapies.

Enter Yiqi Yangyin Huoxue Method

Rooted in TCM principles, the YQYYHX method focuses on invigorating ‘Qi’ (vital energy) and ‘Yin’ (the nurturing aspect of the body’s energetics), as well as promoting blood circulation to counter the effects of diseases. In the context of DR, this approach aims to correct underlying imbalances within the body that contribute to the condition, thereby offering an adjunct or alternative method to the standard care.

Rigorous Analysis Reveals Encouraging Outcomes

Led by Ou Chen and colleagues from the Hunan University of Chinese Medicine, the meta-analysis included data from 10 randomized controlled trials, encompassing 661 patients with DR. The results, which analyzed aspects such as vision improvement, changes in the eye fundus, fundus fluorescence angiography (FFA), TCM syndromes, and hemorheological parameters, indicated that patients who underwent the YQYYHX treatment exhibited significant improvements in these areas compared to those who did not receive it.

Salient Findings and Clinical Implications

Patients treated with YQYYHX were more likely to experience an improvement in vision [risk ratio (RR)=1.32, 95% confidence interval (CI) (1.18, 1.47)], changes in the eye fundus [RR=1.23, 95% CI (1.10, 1.37)], and FFA results [RR=1.33, 95% CI (1.11, 1.60)]. Moreover, improvements in TCM syndromes [RR=1.31, 95% CI (1.15, 1.49)] and a reduction in hemorheological parameters [mean difference (MD) =-0.37, 95% CI (-0.41, -0.32)] were also observed, indicating that treatment led to better blood flow, a key component in managing DR.

Garnering Credibility through Academic Rigor

The methodology underlying this meta-analysis is seen as robust, with an emphasis on data extraction and methodological quality assessment done independently by two reviewers. The statistical analysis was conducted using Rev Man 5.3 software, a gold standard in systematic review analysis. This meticulous approach lends significant weight to the study’s findings.

Reconciling Tradition with Modernity

While TCM has often been viewed with skepticism by practitioners of Western medicine, studies like these underscore the potential benefits of bridging the gap between these healing traditions. With roots going back thousands of years, TCM theories—like those underscoring the YQYYHX approach—have been honed by generations of empirical observations and practices, and their integration with modern scientific methods could offer a holistic path to health that draws from the best of both worlds.

Future Avenues and Cautionary Notes

The study opens avenues for further clinical trials to explore the intricacies of how the YQYYHX treatment interacts with diabetic retinopathy’s pathophysiology. However, as with any meta-analysis, the research is only as conclusive as the data allows, and thus further high-quality, larger-scale randomized controlled trials are necessary to validate these findings before YQYYHX can be widely recommended as a treatment option for DR.

Breaking New Ground for Patient Care

This study’s ramifications for patient care could be substantial, offering a non-invasive and potentially cost-effective treatment alternative that aligns with patients’ preferences for more naturalistic therapies. Traditional systems of medicine such as TCM offer a treasure trove of untapped knowledge that, when validated through rigorous scientific inquiry, could vastly expand our armamentarium against chronic diseases like diabetes and its complications.


The meta-analysis conducted by Ou Chen and colleagues presents compelling evidence that the Yiqi Yangyin Huoxue method could prove to be a significant addition to the diabetic retinopathy treatment landscape. With these positive results, the potential integration of this TCM-based method could revolutionize the approach toward a condition that affects millions. The study not only highlights the effectiveness of traditional methodologies but also opens the door to a more holistic understanding of patient care that respects and includes the wisdom of ancient practices.


1. Cheung N., Mitchell P., Wong T. Y. (2010). Diabetic retinopathy. The Lancet, 376(9735), 124–136. DOI: (
2. Antonetti D. A., Klein R., Gardner T. W. (2012). Diabetic retinopathy. The New England Journal of Medicine, 366(13), 1227–1239. DOI: (
3. Lee R., Wong T. Y., Sabanayagam C. (2015). Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye and Vision, 2(1). DOI:(
4. Yau J. W., Rogers S. L., Kawasaki R., et al. (2012). Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care, 35, 556–564. DOI: (
5. Tang J. L., Liu B. Y., Ma K. W. (2008). Traditional Chinese medicine. The Lancet, 372(9654), 1938–1940. DOI: (

DOI for the Meta-Analysis:
DOI: 10.1155/2019/6020846