Noncommunicable diseases (NCDs) are the leading cause of mortality globally, accounting for nearly 71% of all deaths, according to the World Health Organization. The primary NCDs include cardiovascular diseases, diabetes, cancer, and chronic respiratory diseases, which have been intricately linked to oxidative stress and inflammation as significant underlying mechanisms. Among the various therapeutic strategies and preventive measures, the role of antioxidants, especially vitamin E, has been a topic of interest and intense research. In a recent narrative review published in the Clinical Nutrition ESPEN, researchers have examined the effects of vitamin E supplementation and whether it indeed offers tangible benefits in the context of NCDs.

The Role of Vitamin E

Vitamin E, primarily found in vegetable oils, oilseeds, and nuts, is a lipid-soluble nutrient comprising eight homologous compounds, with α-tocopherol being recognized for its potent vitamin activity. As an antioxidant, it plays a crucial role in cellular protection by scavenging free radicals and reducing oxidative stress. The immunomodulatory and anti-inflammatory actions of vitamin E, particularly through the inhibition of the nuclear factor-kappa B (NF-κB), have also been documented, giving it a multifaceted role in human health.

The Oxidative Stress Link in NCDs

The pathophysiology of many NCDs originates from weakened antioxidant defenses, marked by an increased reactive oxygen species (ROS) production. This imbalance leads to cellular damage, inflammation, and the onset of various chronic conditions. Lipid metabolism disorders, which can be a precursor to cardiovascular diseases, further complicate the risk factors associated with NCDs. In light of these challenges, vitamin E’s therapeutic potential in both preventing and mitigating NCDs has been explored with varying levels of evidence and success.

Supplementation Debate

Despite its purported benefits, skepticism regarding vitamin E supplementation persists in the scientific community. While some studies have shown a positive association between vitamin E intake and the reduction in the risk of certain diseases, others have reported no significant effect or, in some cases, even potential harm. The disparity in outcomes has fueled a debate about the overall efficacy of vitamin E supplements in combating NCDs.

The Clin Nutr ESPEN Review: An Elaborate Analysis

In their exhaustive analysis, Trugilho et al. (2024) aim to clarify the mechanisms by which vitamin E operates and assess the use of supplementation in noncommunicable disease scenarios. The review, titled “Vitamin E and conflicting understandings in noncommunicable diseases: Is it worth supplementing?” published under DOI: 10.1016/j.clnesp.2023.12.147, scrutinizes various studies to derive a more definitive stance on the issue.

Methodology of the Review

Conducted by esteemed researchers from the Fluminense Federal University and the Federal University of Rio de Janeiro in Brazil, and the Centre Hopitalier Lyon Sud in France, the review delved into the mechanistic pathways, clinical trials, and observational studies surrounding vitamin E and its role in NCDs.

Findings and Implications

The evidence indicates that, while there are clear antioxidative and anti-inflammatory benefits attributed to vitamin E, its effectiveness as a supplement in clinical settings remains inconclusive. The study suggests that the varying bioavailability of tocopherols and tocotrienols, different genetic responses to supplementation, and the stage of disease progression may all influence outcome measures.

Critical Analysis and Future Directions

A critical takeaway from the study is the necessity for more targeted research. Future clinical trials should consider factors such as genetics, disease stage, and specific forms of vitamin E to fully understand its potential and limitations.

The Big Picture

Given the massive burden of NCDs on global health systems and economies, the search for effective preventive strategies is more urgent than ever. Vitamins like E play a non-negligible role in maintaining health and potentially reducing disease risk.


The utility of vitamin E supplementation in the prevention and management of NCDs remains a nuanced and complex question. While certain benefits cannot be denied, it seems premature to endorse widespread supplementation without further evidence.


1. Trugilho, L. L., Alvarenga, L. L., Cardozo, L. F. M. F., et al. (2024). Vitamin E and conflicting understandings in noncommunicable diseases: Is it worth supplementing? Clinical Nutrition ESPEN, 59, 343-354. DOI: 10.1016/j.clnesp.2023.12.147
2. World Health Organization. (n.d.). Noncommunicable diseases. Retrieved from
3. Zingg, J.-M., & Azzi, A. (2004). Non-antioxidant activities of vitamin E. Current Medicinal Chemistry, 11(9), 1113-1133.
4. Brigelius-Flohé, R., & Traber, M. G. (2001). Vitamin E: Function and metabolism. The FASEB Journal, 15(10), 1798-1800.
5. Jiang, Q. (2014). Natural forms of vitamin E: Metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radical Biology and Medicine, 72, 76-90.


1. Vitamin E supplementation
2. Noncommunicable diseases
3. Antioxidants and health
4. Oxidative stress and inflammation
5. Tocopherols and tocotrienols