In a groundbreaking study published in Neuroscience Letters on January 11, 2024, a team led by Li Qiang from the Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) has made significant advances in understanding the complex functional topology of brain networks. This research has provided new insights into the correspondences between human and marmoset monkey brains, with far-reaching implications for both neuroscience and comparative biology.

The study, titled “Revealing complex functional topology brain network correspondences between humans and marmosets,” represents a critical step forward in deciphering the architecture of the brain and its connection patterns. By employing topological graph analysis, the TReNDS team has illuminated parallels and dissimilarities in whole-brain functional connectivity between two evolutionarily distant species. With the journal reference DOI 10.1016/j.neulet.2024.137624, the publication signifies an important avenue of research towards understanding the evolution and function of primate brains.

The study’s intricate analysis focused on the investigation of neural connections within brain networks during quiet, resting states as well as during active task engagement. Significantly, the research highlighted commonalities within the dorsal attention network, default mode network, and visual network – critical areas involved in sustaining attention, daydreaming and mind-wandering, and processing visual information respectively. These findings underscore the potential existence of a preserved set of functional systems responsible for similar cognitive and perceptual processes in primates.

To elaborate on their work, Qiang and colleagues assessed the congruency between functional connectivity patterns distributed across the entire brain of humans and marmosets. They identified distinctive patterns unique to each species that underscore the utility of comparative studies in this field. The discovery of these unique neural connections raises questions about their role in species-specific cognitive abilities and behaviors.

The study’s results are published under the article number 137624 and carry the ISSN number 1872-7972. The research was financially and institutionally supported by TReNDS, a coalition involving Georgia State University, Georgia Institute of Technology, and Emory University. The contributions from Qiang, Vince D. Calhoun, and Armin Iraji have been instrumental in pushing the boundaries of our current understanding of functional brain networks.

The implications of this research extend beyond academia to public understanding of brain functionality and disease. Insights gleaned from such comparative studies can inform strategies for tackling neurological conditions that disrupt typical brain connectivity patterns. As such, this study is integral to developing diagnostic tools and therapeutic interventions.

Moreover, by shedding light on the similarities between humans and marmosets, this study also provides a solid foundation for the selection of appropriate non-human primate models in biomedical research. Understanding the functional correspondences between species is pivotal for translating findings from model organisms to human health and disease.

In terms of ethical considerations, the study’s methodology strictly followed the declaration of competing interest, ensuring that the research’s integrity was maintained throughout the process. The authors declared no known competing financial interests or personal relationships that could have influenced the work reported in the paper.

As for the potential expansion of this research, further investigations could explore the functional connectivity patterns in other primate species or delve deeper into the cognitive processes these shared networks support. This could lead to a better grasp of the evolutionary pathways that have shaped the primate brain and its complex functions.


1. Functional Brain Connectivity
2. Human-Marmoset Correspondence
3. Neuroimaging Comparative Study
4. Primate Cognitive Functions
5. Topological Graph Analysis


1. Li, Q., Calhoun, V. D., & Iraji, A. (2024). Revealing complex functional topology brain network correspondences between humans and marmosets. Neuroscience Letters, 137624.
2. Neuroscience Letters. (2024). ISSN 1872-7972.
3. TReNDS – Tri-Institutional Center for Translational Research in Neuroimaging and Data Science. Retrieved from
4. BioRxiv. (2023, November 28). Retrieved January 11, 2024, from
5. Declaration of competing interest in neuroscience research. (2024). Neuroscience Letters, 137624.

In conclusion, this innovative research has unveiled a critical piece of the puzzle regarding the functional correspondences within the primate brains.issenschafts community to explore and understand further. With the dedicated efforts of researchers like Qiang and his team, a new era of neuroscience exploration is on the horizon.