Researchers and dermatologists alike are turning their focus towards natural remedies and bioactive compounds as potential sources for treating various skin conditions. One such bioflavonoid garnering significant attention is hesperidin. With a high concentration in citrus fruits, hesperidin’s reputation has been bolstered not only for its well-known cardiovascular and anti-diabetic benefits but, more importantly, for its multiple cutaneous functions. Recent studies have shed light on the impressive range of benefits hesperidin offers, including wound healing, UV protection, anti-inflammatory effects, antimicrobial activity, anti-skin cancer properties, and skin lightening effects, with additional promising implications for aging skin.

Revolutionizing Skin Health: Hesperidin’s Bioactive Properties

The hesperidin revolution is rooted in its potent antioxidant properties, which afford considerable protection against various stressors at the skin level. In particular, hesperidin targets the inhibition of MAPK-dependent signaling pathways and stimulates the production of epidermal proliferation, differentiation, and lipids, essential for maintaining barrier homeostasis in both young and aged skin. Such multifaceted benefits have positioned hesperidin as a promising candidate for the management of a diverse array of cutaneous conditions.

These compelling insights into hesperidin’s role in skin health were featured in the “Evidence-based Complementary and Alternative Medicine” journal, delineated by Man Mao-Qiang et al. (DOI: 10.1155/2019/2676307). This review article has detailed the mechanistic pathways through which hesperidin exerts its dermatological effects, offering hope for safer, more effective treatment regimens.

Hesperidin and Healing: The Wound-Healing Maestro

In the realm of cutaneous repair and wound healing, hesperidin has shown remarkable efficacy. Its anti-inflammatory and antioxidant prowess mitigate oxidative stress, which is pivotal during the wound-healing process (Wang L. et al. 2018, doi: 10.1177/2058739218775255). More specifically, hesperidin enhances the expression of crucial growth factors and proteins like TGF-β, which play instrumental roles in wound recovery and tissue regeneration (Li W. et al. 2018, PMC5962903).

Shielding Skin from the Sun: UV Protection Personified

Exposure to UV radiation is a significant risk factor for various skin issues, including photoaging and skin cancer. Hesperidin steps in as a natural photoprotective agent, attenuating UV-induced apoptosis in human keratinocytes (Hewage S. R. et al. 2016, PMC4859795). It accomplishes this by bolstering skin defenses and repairing DNA damage, pointing towards its potential usage in sun care products.

A Soothing Touch for Inflamed Skin

The anti-inflammatory aspect of hesperidin is one of its most celebrated features in dermatology. Research has shown that hesperidin can significantly reduce key markers of inflammation, such as COX-2 expression and prostaglandin E2 production, thereby offering a calming effect on inflamed skin conditions like atopic dermatitis and psoriasis (Brunner P. M. et al. 2017, PMC5562859).

An Anti-Cancer Ally

As research advances, hesperidin continues to demonstrate potential as an anticancer agent for skin. Its capability to initiate apoptotic mechanisms in cancerous cells while sparing healthy cells sets it apart as a notable chemopreventive compound (Smina T. P. et al. 2015, doi: 10.14715/cmb/2015.61.6.12).

Ingredients of Youth: Anti-Aging Activities

Concerning aging and the aesthetic dimension of dermatology, hesperidin has shown potential in improving the features of aged skin. It not only improves epidermal function but also contributes to the reduction of wrinkle depth and fine lines, reflecting improved dermal health (Man G. et al. 2015, PMC4366273).

Does the Efficacy of Hesperidin Translate to the Market?

Amidst the rise of hesperidin’s reputability in clinical settings, its impact on the cosmetic market has been substantial. Consumers are increasingly drawn to products that contain natural bioflavonoids with scientifically-backed benefits. In China, for example, the market status of skin care products that integrate compounds like hesperidin is rising, reflecting a global trend towards bioactive-infused cosmetics (

Safety and Accessibility: Hesperidin’s Dual Advantages

Among the many advantages of hesperidin, its safety profile stands out conspicuously. Unlike many pharmacological agents that may pose risks or adverse effects with prolonged use, hesperidin exhibits a superior safety record. Moreover, its low cost and wide availability make it an attractive ingredient for both pharmaceutical and cosmetic use. This is pivotal as the skincare industry battles the challenges of adverse cutaneous reactions to beauty products, which vary significantly with age and gender (Huang L. et al. 2018, PMC6234074).

Hesperidin’s Dermatological Horizon: Looking Ahead

The comprehensive review by Man Mao-Qiang et al. opens doors to new dermatological possibilities for hesperidin (DOI: 10.1155/2019/2676307). While further clinical trials and longitudinal studies are essential to cement its standing in treatment protocols, this citrus bioflavonoid offers a brighter future for dermatology—raising hope for millions worldwide seeking answers for their skin conditions.


1. Hesperidin
2. Skin Health
3. Citrus Bioflavonoid
4. Dermatological Benefits
5. Natural Skin Care


1. Man Mao-Qiang, Bin Yang, Peter M. Elias (2019). Benefits of Hesperidin for Cutaneous Functions. Evidence-based Complementary and Alternative Medicine. DOI: 10.1155/2019/2676307
2. Wang L, He T, Fu A, et al. (2018). Hesperidin enhances angiogenesis via modulating expression of growth and inflammatory factor in diabetic foot ulcer in rats. European Journal of Inflammation. DOI: 10.1177/2058739218775255
3. Li W, Kandhare AD, Mukherjee AA, Bodhankar SL. (2018). Hesperidin, a plant flavonoid accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats: Role of TGF-B/SMADS and ANG-1/TIE-2 signaling pathways. EXCLI Journal. PMC5962903
4. Hewage SR, Piao MJ, Kang KA, et al. (2016). Hesperidin attenuates ultraviolet B-induced apoptosis by mitigating oxidative stress in human keratinocytes. Biomolecules & Therapeutics. DOI: 10.4062/biomolther.2015.139. PMC4859795
5. Brunner PM, Suárez-Fariñas M, He H, et al. (2017). The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins. Scientific Reports. DOI: 10.1038/s41598-017-09207-z. PMC5562859
6. Man G, Mauro TM, Zhai Y, et al. (2015). Topical hesperidin enhances epidermal function in aged murine skin. Journal of Investigative Dermatology. DOI: 10.1038/jid.2014.486. PMC4366273
7. Huang L, Zhong Y, Liu D, et al. (2018). Adverse cutaneous reactions to skin care products on the face vary with age, but not with sex. Contact Dermatitis. DOI: 10.1111/cod.13102. PMC6234074

Categorized in:

Health News,

Last Update: February 3, 2024