In the realm of pediatric oncology, hematopoietic stem cell transplantation (HSCT) is recognized as a pivotal treatment for a broad spectrum of maladies, both of benign and malignant nature. A case recently reported in the respected journal Contemporary Oncology (Poznan, Poland) has brought to light a rare but grave complication linked to this procedure.

DOI: 10.5114/wo.2019.83815

A 4-year-old girl, suffering from metastatic neuroblastoma, underwent autologous HSCT and subsequently developed autologous graft-versus-host disease (GVHD), a condition typically observed in allogeneic HSCT where donor cells attack the recipient’s body. However, in autologous HSCT, where a patient receives their own previously harvested cells, the occurrence of GVHD is strikingly uncommon, making this case remarkable and worthy of extensive discussion within the medical community.

Yaman Yöntem, Gökhan Baysoy, Emre Keleşoğlu, Kürşat Özdilli, Aslı Çakır, Dildar Bahar Genç, Murat Elli, and Sema Anak, the authors of the study affiliated with Medipol University in Istanbul, Turkey, documented this unusual instance to shed light on the occurrence of autologous GVHD which points to the potential recognition of host self-antigens as foreign by the immune system.

The comprehensive report detailing the case was published in the 2019 issue of Contemporary Oncology (Poznan, Poland), under the title “Graft-versus-host disease in a child with neuroblastoma after autologous stem cell transplantation.”

The Peculiarity of Autologous GVHD

Traditional understanding of GVHD underscores its association with allogeneic HSCT, in which a donor and recipient are involved. Yet scientifically, it remains enigmatic how GVHD develops after autologous HSCT as there is no introduction of foreign cells to elicit such a response.

Investigation and Diagnosis

The diagnosis of autologous GVHD can be challenging due to its infrequency, but it is crucial to address as it incurs considerable morbidity and mortality. The case report emphasizes the importance of being vigilant for signs of GVHD post-autologous HSCT. Such vigilance allows for early diagnosis which is vital for implementing timely and effective treatment.

Implications and Management

The occurrence described by the study in Contemporary Oncology confers new considerations in the management of HSCT patients. This includes the need for a unified approach towards diagnosis and tailored therapeutic strategies to mitigate the consequences of autologous GVHD.


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1. Autologous Stem Cell Transplantation
2. Pediatric Graft-versus-Host Disease
3. Neuroblastoma Treatment Complications
4 Hematopoietic Stem Cell Transplantation
5. Autologous GVHD in Children


This singular case provides an impactful addition to the medical literature surrounding stem cell transplantation and its accompanying risks. Recognizing this as an opportunity for learning and adaptability, the pediatric oncology field can continue to evolve in its approaches, ensuring a critical balance between effective disease management and the prevention of such unusual but significant post-transplantation complications. The authors have opened a conduit for further research and discussion through their meticulous documentation and analysis of this case, contributing to better treatment outcomes for young patients in similar predicaments.