April 8, 2022 – A recent study published in “Contemporary Oncology (Poznan, Poland)” has highlighted significant findings regarding laparoscopic liver resection (LLR) in patients with coexisting cardiac disease, emphasizing the importance of perioperative management and patient selection to optimize surgical outcomes. The retrospective review conducted by Inoue et al., presents a comprehensive analysis of patients who underwent LLR at Osaka Medical College Hospital between 2010 and 2018.

DOI: 10.5114/wo.2019.84109


1. Laparoscopic Liver Resection
2. Cardiac Disease Management
3. Surgical Outcomes
4. Perioperative Care
5. Comorbidity in Surgery

The Survey of Laparoscopic Liver Resection in Cardiac Patients

The gravest challenge confronting modern medicine is the management of an aging population and the concurrent rise in age-associated comorbidities, such as cardiac disease. Inoue et al.’s study, which examined 339 LLR cases, provides valuable insights into how LLR can be safely performed on patients with cardiac disease – an insight crucial for managing a demographic increasingly needing both oncologic and cardiac care.

Preoperative Status

The study identified 16 of the 338 patients with cardiac comorbidities, exhibiting a mean left ventricular ejection fraction (LVEF) of 66%. These patients had their cardiac disease under control prior to the LLR procedure, ensuring no incidents of increased central venous pressure (CVP) or destabilized vital signs occurred during surgery.

The Perioperative Outcomes

The authors meticulously compared intraoperative CVP and other vital parameters between patients with and without cardiac disease. Remarkably, the data showed no significant variance in these metrics, suggesting that controlled cardiac disease does not complicate LLR procedure.

Postoperative Courses

Postoperative recovery is a critical concern for patients with comorbidities. Inoue et al. observed no considerable difference between the postoperative progress of patients with non-severe or managed cardiac disease and those without cardiac complications. This finding is pivotal for surgical planning and patient reassurance.

Case for Prioritizing Cardiac Treatment

The research also provides a cautionary note: uncontrolled severe cardiac disease can lead to intraoperative instability, evidenced by increased CVP. Therefore, treating the cardiac disease should be prioritized to render patients eligible for LLR safely.


1. Inoue Y, Kagota S, Tsuchimoto Y, et al. Laparoscopic liver resection for patients with cardiac disease. Contemp Oncol (Pozn). 2019;23(1):37-42. doi:10.5114/wo.2019.84109
2. Hosokawa I, Allard MA, Mirza DF, et al. Outcomes of parenchyma-preserving hepatectomy and right hepatectomy for solitary small colorectal liver metastasis: A LiverMetSurvey study. Surgery. 2017;162:223-232. doi:10.1016/j.surg.2017.01.031
3. Inoue Y, Suzuki Y, Fujii K, et al. Laparoscopic Liver Resection Using the Lateral Approach from Intercostal Ports in Segments VI, VII, and VIII. J Gastrointest Surg. 2017;21:2135-2143. doi:10.1007/s11605-017-3497-0
4. Inoue Y, Hayashi M, Tanaka R, et al. Short-term results of laparoscopic versus open liver resection for liver metastasis from colorectal cancer: a comparative study. Am Surg. 2013;79:495-501.
5. Epstein M. Effects of aging on the kidney. Fed Proc. 1979;38:168-171. PMID: 367819

Discussion of Findings

The study by Inoue et al. significantly contributes to the ongoing discussion of expanding criteria for resectability of tumors among patients with additional comorbidities. The positive outcomes suggest that LLR can potentially be extended to those with controlled cardiac disease without compromising patient safety. Furthermore, it sheds light on the tailored perioperative cardiac care that is fundamental for successful surgical interventions.

Implications for Future Research and Clinical Practice

The implications of these findings are vast, potentially affecting clinical guidelines, patient selections, preoperative preparations, and intraoperative monitoring practices. Further research is needed to explore the interaction between cardiac care and surgical oncology, but studies such as this one by Inoue et al. pave the way for such endeavor.

Personalized Care Pathways

The concept of personalized medicine extends beyond oncology into surgical practices, especially in managing complex cases such as those presented by Inoue et al. Individual patient evaluations and preparation, specifically in the cardiology arena, are evidently paramount. The success of LLR in patients with coexisting cardiac conditions attests to the importance of personalized care pathways.


Through thorough patient selection and perioperative management, Inoue et al.’s study strongly supports that LLR can be safely and successfully performed in patients with cardiac diseases. As societies continue to age and the incidence of comorbid conditions increases, findings such as these will be critical for developing safe and effective surgical strategies to manage cancer in this complex patient population.

In summary, thanks to the meticulous research by Inoue and colleagues, the discourse on LLR in patients with cardiac disease has been pushed forward. With no increase in adverse outcomes evident for those with managed cardiac conditions, LLR represents an option that offers promise for a wider range of patients, providing equitable access to state-of-the-art oncological care.

The significant advances in surgical techniques, perioperative management, and interdisciplinary cooperation converge in this study, illustrating the potential for improved patient outcomes. It is a testament to the evolving realm of medical care, where the lines between specialties blur to meet the multifaceted needs of each patient. In light of these findings, the medical community continues to stride toward precise, comprehensive, and compassionate care.