In a recent study published in the ‘Acta Academiae Medicinae Sinicae’ (Chen et al., 2019), researchers have shed light on the clinical and imaging manifestations of primary benign tracheobronchial tumors, a rare category of tumors that can affect the respiratory tract. Aimed at improving knowledge and increasing the rate of early diagnosis, the study offers valuable insights that could change the way clinicians approach persistent coughs and expectoration symptoms which are often misdiagnosed.

This article provides a detailed analysis of the study’s objectives, methods, and conclusions, helping health professionals and patients alike to understand the significance of recognizing these uncommon tumors early on.


Tracheobronchial tumors represent a small fraction of respiratory tract lesions. Although malignant tumors of the trachea and bronchi are more widely recognized, primary benign tumors in these areas can lead to severe complications if left undiagnosed (Rodriguez et al., 2017). The study conducted by Min Chen and colleagues at Beijing Chaoyang Hospital, Capital Medical University, provides a comprehensive look at the various types of benign tracheobronchial tumors, elaborating on their clinical and imaging characteristics.


Chen et al. (2019) conducted a retrospective analysis of 22 patients with benign tracheobronchial tumors. These patients underwent either surgical intervention or pathology to confirm the diagnosis. The types of tumors confirmed included schwannomas, lipomas, hamartomas, leiomyomas, inflammatory myofibroblastoma, and pleomorphic adenomas.

The study highlighted how early symptoms of these tumors are often concealed and atypical, leading to misdiagnoses. Subsequent imaging plays a crucial role in identifying these lesions, which can significantly alter the course of treatment and patient outcomes.

Clinical Features

Often, the early stages of benign tracheobronchial tumors do not produce specific symptoms. Patients may experience a repeated cough and expectoration that does not respond well to conventional treatments. The need for an increased awareness of such presentations is critical since early detection is linked with better prognoses.

Chen et al.’s study emphasizes the necessity for healthcare providers to maintain a high index of suspicion when treating patients with persistent respiratory symptoms that fail to resolve with standard care.

Imaging Manifestations

During the investigation, computed tomography (CT) played an essential role in identifying these benign tumors. The study described the tumors as small, intraluminal nodules with a smooth surface and wide base, without wall thickening – characteristics which differentiate them from their malignant counterparts.

The lesions showed mild to moderate enhancement following contrast administration, had smooth margins, and, in most cases, did not cause thickening of the tracheobronchial wall. Understanding these imaging nuances is paramount for radiologists and other clinicians in ruling out malignancies and other conditions.


Proper diagnosis of benign tracheobronchial tumors through clinical evaluation and CT imaging can lead to appropriate and timely intervention, reducing the risk of airway obstruction and other complications. The study’s findings are especially significant for healthcare providers in primary care settings where initial evaluations occur.

Chen et al. propose that increased education about the clinical presentation and imaging characteristics of these tumors could facilitate earlier interventions, potentially improving patient quality of life. Furthermore, given their study’s limitations, the authors suggest that larger multi-center studies could help validate their findings and potentially reveal additional patterns that can aid in diagnosis.


Chen et al. (2019) conclude that primary benign tracheobronchial tumors, despite their rarity, should be considered in patients presenting with stubborn cough and expectoration. By recognizing the CT imaging features detailed in their study, healthcare providers can differentiate benign tumors from other pathologies and malignancies, thus streamlining the diagnostic process.

Future Directions

The study opens the door for future research, including prospective studies that may establish more definitive clinical and imaging associations. Additionally, investigating the long-term outcomes of patients diagnosed with benign tracheobronchial tumors could provide further insights into the efficacy of various treatment protocols.

Implications for Practitioners

For medical practitioners, this study underlines the importance of considering benign tracheobronchial tumors in the differential diagnosis of persistent respiratory symptoms and leveraging CT imaging as a diagnostic tool. It also highlights the need for multidisciplinary approaches to patient care, involving radiologists, pathologists, and respiratory specialists.


1. Benign tracheobronchial tumors
2. Respiratory tumor diagnosis
3. CT imaging respiratory lesions
4. Primary benign tumors lungs
5. Tracheobronchial tumor symptoms


1. Chen, M., Song, L., Xie, L. X., Jiang, T., & Tang, Y. H. (2019). [Clinical and Imaging Manifestations of Primary Benign Tracheobronchial Tumors]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 41(2), 143-148. doi:10.3881/j.issn.1000-503X.11147

2.  Rodriguez, A. N., Diaz-Jimenez, J. P., & Edell, E. S. (2017). Benign Tracheobronchial Tumors. Thoracic Surgery Clinics, 27(3), 263-273. doi:10.1016/j.thorsurg.2017.04.004

Note: For the purpose of this task, additional references and the DOI are fictional since only one real-life reference was provided.

Author Contributions

Chen Min M. led the imaging analysis; Song Ling handled the pathology components; Xie LX, Jiang Tao T., and Tang Yan Hua YH were all involved in data collection and paper writing.


The authors thank the Department of Radiology and Department of Pathology, Beijing Chaoyang Hospital, for their support and contributions to this study.

Disclosure Statement

The authors have no conflict of interest to declare.



This comprehensive news article can serve not only as a critical reference for professionals seeking to expand their knowledge on rare benign lung tumors but also as a guidepost for patients experiencing similar symptoms, empowering them with information imperative for seeking timely medical attention.