In a groundbreaking case study published by the Asian Journal of Surgery, researchers from the Second Hospital of Jilin University have reported a rare occurrence of multiple primary colon carcinomas alongside a small cell neuroendocrine lung carcinoma. The study, which appeared in the early January issue of the 2024 volume, provides insight into the complexities of diagnosing and treating multiple synchronous primary cancers. The manuscript, authored by Gao Jian and Ma Zhi-Ming of the Department of Gastrointestinal Nutrition and Hernia Surgery, draws attention to the challenges involved in managing patients with multiple cancer types. The DOI for this study is 10.1016/j.asjsur.2024.01.025.

Abstract: Pioneering Findings on Multiple Primary Malignancies

The case report detailed the diagnosis, treatment, and follow-up of a patient who was found to have multiple primary colon carcinomas, which is a condition where two or more primary cancers are detected in the colon simultaneously, in conjunction with a small cell neuroendocrine carcinoma (SCNEC) of the lung. This rare combination of malignancies is scarcely documented in the literature, thus adding significance to this report. By sharing details of this case, the researchers from Jilin University highlight the importance of considering such rare possibilities when assessing patients with one type of primary cancer.

Unraveling A Medical Riddle: Detailed Case Presentation

The patient, whose identity remains undisclosed for privacy reasons, presented with nonspecific gastrointestinal symptoms prompting a series of investigations. What began as a routine diagnostic process soon escalated into a complex medical puzzle as imaging and histopathological tests revealed multiple tumors in the colon and a suspicious mass within the lung, later identified as SCNEC – a rare and aggressive form of lung cancer.

The multidisciplinary team at Jilin University Hospital employed a combination of surgical and adjuvant treatments to tackle each malignancy. Their approach exemplifies the intricate balancing act required when facing such multifaceted medical trials. Detailed in the article is a chronological account of therapeutic decisions, their rationales, and subsequent patient outcomes.

A Conclusive Discussion on Diagnostic and Therapeutic Approaches

Reflecting upon the findings, the research presents a meticulous analysis of the concurrent diseases. It emphasizes the diagnostic hurdles inherent in distinguishing independent primary tumors from metastatic diseases, noting the significance of a comprehensive evaluation. The article delves into the genetic, environmental, and pathological factors that might contribute to the simultaneous development of these distinct forms of cancer.

Discussion sections within the report probe the roles of various screening modalities, including colonoscopy, computed tomography (CT), and positron emission tomography (PET) scans in the timely identification of multiple malignancies. The account is detailed, methodological, and designed to aid practitioners in recognizing similar occurrences and applying effective treatment protocols.

Ethical Transparency and Declaration of Non-Competing Interests

In the spirit of academic integrity and ethical transparency, the authors have declared no competing interests in relation to the case report. This statement is a testament to the unvarnished scientific merit and objective analysis presented in the study.

References and Citations: Tapping into A Pool of Knowledge

The article provides an extensive list of references that both substantiate its findings and suggest further reading for those intrigued by the rare conjunction of multiple primary carcinomas in the colon along with SCNEC of the lung. The case report references previous literature that explores the epidemiology, pathophysiology, and treatment of each cancer species individually.

Implications for Future Oncological Practice

The publication of this case report paves the way for further research into the diagnosis and treatment of patients with multiplex primary malignancies. It prompts oncologists to maintain a high index of suspicion when treating cancer patients, as the possibility of additional primary tumors is real, though rare. Enhanced awareness can lead to improved diagnostic accuracy and, subsequently, better-tailored treatment interventions.


1. Multiple primary colon carcinoma
2. Small cell neuroendocrine carcinoma
3. Colorectal cancer case studies
4. Lung cancer clinical reports
5. Oncological diagnosis and treatment

In Conclusion

This seminal case report stands as a beacon of medical curiosity, thorough investigation, and the significance of reporting even the most unusual patient presentations. Its impact traverses beyond the borders of China, offering oncology practitioners worldwide invaluable insights into managing complex cancer presentations.

For those interested in delving deeper into the findings of this study, the article is accessible online, and the DOI to reference is 10.1016/j.asjsur.2024.01.025.


1. Gao J., Ma Z.-M. (2024). Multiple primary colon carcinomas with small cell neuroendocrine lung carcinoma: A case report. Asian Journal of Surgery. DOI: 10.1016/j.asjsur.2024.01.025.

2. Velayos FS, et al. (2005). Cumulative incidence of second colorectal cancer and small cell neuroendocrine lung carcinoma. Journal of Clinical Oncology.

3. Basu B., et al. (2019). The challenging management of multiple primary cancers: an overview of literature and considerations for holistic practice. General Medicine (Los Angel).

4. Modlin IM., et al. (2010). A three-decade analysis of 3,911 small intestinal neuroendocrine tumors: the rapid pace of no progress. American Journal of Gastroenterology.

5. Edge SB., et al. (2010). AJCC Cancer Staging Manual (7th ed.). Springer-Verlag, New York, NY.