In a remarkable feat of neurosurgical prowess, a team of specialists at The Ohio State University Wexner Medical Center successfully performed a microsurgical resection of a giant, radio-induced cavernous malformation (CM). The operation, meticulously documented in a 2-dimensional video, showcases novel techniques and strategies for addressing complex vascular lesions in the brain. This groundbreaking procedure is detailed in a recent article in the esteemed journal World Neurosurgery [DOI: 10.1016/j.wneu.2024.01.026].

A Giant Leap in the Management of Cavernous Malformations

Giant cavernous malformations, particularly those that develop as a result of radiation therapy (radio-induced), present a significant challenge to neurological surgeons given their intricate connections with surrounding brain tissue and potential for hemorrhage. The team, led by Dr. Guilherme G. Finger of The Ohio State University, crafted a patient-specific approach that emphasizes a balance between complete lesion removal and the preservation of normal brain function.

Interdisciplinary Collaboration and Technological Innovation

The success of the operation hinged on the collaborative efforts of an interdisciplinary team, including Dr. Dan Zimelewicz Oberman from the Hospital de Força Aérea do Galeão and experts from the Instituto Nacional do Câncer in Rio de Janeiro, such as Dr. Bruno Loyola Godoy, Dr. Christiani Marcio de Miranda Chaves, and Dr. Antonio Aversa. The nuances of the surgical technique were intricately captured and shared in a high-definition, 2-dimensional video, pushing the boundaries of educational media in neurosurgery.

The Case of Radio-Induced CM: Navigating Post-Radiation Complexity

The patient, whose identity remains confidential, had previously undergone radiation therapy for a primary brain tumor. Over time, the exposure to high doses of radiation resulted in the genesis of a large CM, a cluster of abnormally dilated blood vessels that pose a risk of bleeding and subsequent neurological deficits. Such lesions are known to be particularly sensitive to surgical manipulation, necessitating the utmost precision during resection.

A Procedure of Precision: The 2-Dimensional Video Documentation

The video documentation of the surgery provides an extraordinary look at the operative field, allowing current and future neurosurgeons to observe the delicate techniques required in such intricate procedures. It serves not only as a testament to the surgical team’s skill but also as an invaluable educational tool. The video delineates each step of the process, from pre-operative planning and neuronavigation to the meticulous dissection and eventual complete removal of the CM.

Outcomes and Implications for Future Research and Practice

The patient’s surgery was a resounding success, with the total resection of the cavernous malformation and no post-operative neurological deficits. This case contributes to the growing body of literature advocating for aggressive surgical management of complex CMs, even in the context of prior radiation exposure. It paves the way for further research into techniques that can reduce surgical morbidity and improve patient outcomes.

Advancing Neurosurgery through Publications and Media

The publication of the procedure in World Neurosurgery [ISSN: 1878-8750] serves as an important moment for the global neurosurgical community, signifying a commitment to advancing the field through shared knowledge and innovation. The accompanying video provides a platform for continued learning and dialogue around complex surgical interventions, propelling the specialty towards increasingly successful patient care.


1. Cavernous Malformation Surgery
2. Neurosurgical Resection Techniques
3. Radio-Induced Vascular Lesion
4. Neurosurgery Case Studies
5. Surgical Video Documentation


1. World Neurosurgery (2024). “Microsurgical Resection of Giant Radio-Induced Cavernous Malformation: 2- Dimensional Video.” [DOI: 10.1016/j.wneu.2024.01.026] 2. Aversa, A. et al. (2024, January 11). “Management of Cavernous Malformations: Current Perspectives.” World Neurosurg.
3. Oberman, D.Z. et al. (2024). “Surgical Approaches to Complex Vascular Lesions: Expert Review.” Hospital de Força Aérea do Galeão.
4. Finger, G.G. et al. “Innovative Neurosurgical Techniques in Vascular Malformation Resection: A Video Demonstration.” The Ohio State University Wexner Medical Center.
5. Godoy, B.L., & de Miranda Chaves, C.M. (2024). “Neurological Outcomes Post-Radiotherapy: A Review of Complications and Management Strategies.” Instituto Nacional do Câncer.