In an era where food safety is of paramount importance, a groundbreaking study published on February 1, 2024, in the prestigious ‘Analytica chimica acta’ journal has unveiled an innovative detection method for anthelmintic residues in animal-origin food. This novel approach not only marks a significant advancement in food safety protocols but also assures a higher standard of health for consumers globally. Let’s delve deep into this scientific development that harnesses the power of fluorescent sensors.

Introduction to the Challenge

Albendazole (ABZ), a benzimidazole-based anthelmintic, is commonly used in veterinary medicine to combat helminth infections in livestock. However, the improper administration of ABZ can lead to residues in animal-origin food, posing serious health risks to humans including potential anthelmintic resistance. Alarming as it is, the metabolite of ABZ, known as albendazole sulfoxide (ABZSO), further complicates the issue by also exhibiting toxic effects. Consequently, harnessing reliable methods to detect these compounds is not a matter of choice but necessity.

The Breakthrough Solution

In light of these concerns, researchers led by Bao Guang-Ming at the National “111” Center for Cellular Regulation and Molecular Pharmaceutics, along with the Key Laboratory of Fermentation Engineering (Ministry of Education) and several other eminent institutions, have developed an innovative dual-emission europium fluorescent sensor (EuUHC-30). This rationally designed sensor showcases an astonishingly high selectivity and sensitivity towards ABZ and ABZSO with detection limits standing at 0.10 and 0.13 µM respectively – a leap in analytical methods employed thus far.

The Science Behind EuUHC-30

The dual-emissive properties of EuUHC-30 originate from its unique metal-organic framework (MOF), which employs europium (Eu) ions. The interaction between the target analytes (ABZ and ABZSO) and the Eu(III) centers within the framework facilitates a change in the luminescence of the sensor. This luminescence shift can be detected and measured quantitatively, providing an accurate assessment of the concentration of these anthelmintic compounds in food samples.

Application in the Real World

Most impressively, the practicality of this research is underlined by its application in common animal-derived foods. The team successfully implemented EuUHC-30 for the quantification of ABZ and ABZSO in milk and pig kidney. These results were subsequently verified through complementary High-Performance Liquid Chromatography (HPLC) analyses, confirming the effectiveness of the MOF-based sensor.

To bring this innovation to the masses, the researchers further engineered a smartphone-assisted EuUHC-30 fluorescent paper sensor. This low-cost, accessible gadget empowers both professionals and laypeople—in regions with varying levels of technological advancement—to perform practical determinations of ABZ and ABZSO residues in real food samples. Thus, it introduces visual, rapid, and intelligent detection into the everyday sphere.

Technological Integration and Future Outlook

Lighting the path forward, such technology could revolutionize the way food quality is monitored in various sectors of the food industry. The integration with smartphones, in particular, leans into the contemporary trend of smart technology and reflects an understanding of the need for accessible, user-friendly tools in science and safety protocols.

The Importance of Sharing Knowledge

The team’s declaration of no known competing financial interests or personal relationships ensures the integrity of the study, allowing the scientific community and industry stakeholders to fully trust and potentially adopt this technology. The DOI for this publication is 10.1016/j.aca.2023.342196, making it easy for peers to locate and cite this seminal work in future research.


One should note that the following references highlight similar research fields and offer background on the importance of food safety and the use of metal-organic frameworks in detection methods.

1. Huxley, J. K., et al. “Recent Developments in the Application of Metal-Organic Frameworks for the Detection of Veterinary Drugs in Foods.” Journal of Agricultural and Food Chemistry (2021).
2. Fernández-Bayo, J. D., et al. “Understanding and Mitigating the Effects of Anthelmintic Residues in Agroecosystems.” Environmental Pollution (2022).
3. Wu, D., et al. “Metal-Organic Frameworks-Based Biosensors for Food Safety Detection.” Biosensors and Bioelectronics (2020).
4. Dai, H., et al. “Fluorescent Metal-Organic Framework Composites for the Detection of Pesticide and Veterinary Drug Residues.” Advanced Functional Materials (2021).
5. Eltzov, E., et al. “Rapid and Sensitive Detection of Veterinary Drug Residues in Food Using Field-Effect Transistors.” Scientific Reports (2023).


1. Food Safety Detection Methods
2. Albendazole Residue Sensing
3. Metal-Organic Framework (MOF) Sensors
4. Fluorescent Eu(III) Complex
5. Mobile-Assisted Food Quality Control


In conclusion, the development of EuUHC-30 as a dual-emissive sensor represents a substantial step forward in ensuring the safety of animal-origin food. As interdisciplinary research continues to flourish, we eagerly anticipate further enhancements that may stem from this achievement, making our food supply safer, and ultimately, protecting public health globally.