In a groundbreaking study recently published in the prestigious “Zhonghua Xin Xue Guan Bing Za Zhi” journal, a team of medical researchers from the Department of Cardiology at Beijing Hospital, National Center of Gerontology, and the Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, has established a novel echocardiographic two-dimensional strain evaluation method to assess right ventricular (RV) function in healthy adults with unprecedented precision. This research, conducting a cross-sectional study, has the potential to revolutionize the way clinicians monitor and manage conditions affecting the right side of the heart.


Right ventricular function is a critical determinant of cardiovascular health, yet its assessment has remained a challenge for clinicians due to the complexity of RV anatomy and function. Traditional imaging techniques, such as standard two-dimensional echocardiography, have provided limited insight into RV performance. However, the introduction of two-dimensional strain imaging has the potential to change this narrative by offering a more precise evaluation of the right ventricle’s movements and contractions.

The objective of this new study, as detailed in the article with DOI: 10.3760/cma.j.cn112148-20231019-00348, was to validate the reliability of this echocardiographic technique in assessing right ventricular function among a healthy adult population. In doing so, researchers Li Y, Guo Y, Xia C, Meng X, Wang X, Xu T, Zhong Y, and Wang F set out to provide the medical community with a reliable and non-invasive method to evaluate RV function more accurately.


The study employed rigorous methodologies to assess the reliability of its echocardiographic two-dimensional strain measurement. A substantial sample size of healthy adults was recruited to participate in the cross-sectional study, ensuring diversity in age, gender, and health status. Participants underwent detailed echocardiographic imaging, focusing on evaluating the strain of the right ventricle – a measure of the deformation of the ventricle during the cardiac cycle.

To ensure the precision and reproducibility of the results, the study applied the Intraclass Correlation Coefficient (ICC) as a statistical measure for the assessment of inter-observer and intra-observer variability. The ICC is a crucial indication of the level of agreement and reliability among measurements taken by different observers or by the same observer at different times.


The findings from the study are notable. The reported ICC values were significantly high, indicating excellent reproducibility and low variability in the measurements taken by different observers and across multiple assessments. With P-values consistently below the significance threshold, the study presents a compelling case for the echocardiographic two-dimensional strain technique as a reliable tool for the evaluation of right ventricular function.

The results also illustrate that the method can produce consistent and repeatable measurements, which is essential for clinical practice where serial assessments of the same patient are common. The implications of these findings are significant as they can enhance the early diagnosis and treatment of conditions such as amyotrophic lateral sclerosis, ventricular dysfunction, and other heart diseases affecting the RV.


The study concludes that echocardiographic two-dimensional strain evaluation is a reliable and non-invasive method to assess right ventricular function in healthy adults. It sets a new standard for RV function evaluation, showing potential for application in both clinical practice and research settings.

Implications for the Future

This research represents a vital step forward in cardiac health. The findings suggest that, with the reliable echocardiographic two-dimensional strain technique, early detection and better management of diseases affecting the right ventricle are possible. It may also affect treatment strategies and improve the quality of life for patients with RV-related cardiac conditions.

Future studies are likely to explore the application of this technique in various patient populations, including those with existing RV conditions, to further understand its utility across different cardiac scenarios.


For researchers and practitioners interested in delving deeper into the details of this study, the following references are essential for a comprehensive understanding:

1. Li, Y., Guo, Y., Xia, C., Meng, X., Wang, X., Xu, T., Zhong, Y., & Wang, F. (2024). Echocardiographic two-dimensional strain evaluation of right ventricular function in healthy adults. Zhonghua Xin Xue Guan Bing Za Zhi, 52(1), 58-63. doi: 10.3760/cma.j.cn112148-20231019-00348.

2. Voigt, J.U., Pedrizzetti, G., Lysyansky, P., Marwick, T.H., Houle, H., Baumann, R., Pedri, S., Ito, Y., Abe, Y., Metz, S., Song, J.H., Hamilton, J., Sengupta, P.P., Kolias, T.J., d’Hooge, J., Aurigemma, G.P., Thomas, J.D., & Badano, L.P. (2015). Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging. European Heart Journal – Cardiovascular Imaging, 16(1), 1-11.

3. Haddad, F., Hunt, S.A., Rosenthal, D.N., & Murphy, D.J. (2008). Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation, 117(11), 1436-1448. doi: 10.1161/CIRCULATIONAHA.107.653576.

4. Lang, R.M., Badano, L.P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F.A., Foster, E., Goldstein, S.A., Kuznetsova, T., Lancellotti, P., Muraru, D., Picard, M.H., Rietzschel, E.R., Rudski, L., Spencer, K.T., Tsang, W., & Voigt, J.U. (2015). Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal – Cardiovascular Imaging, 16(3), 233-271.

5. Henein, M.Y., & Gibson, D.G. (1999). Long axis function in disease. Heart, 81(3), 229-231.


1. Echocardiographic strain imaging
2. Right ventricular function
3. Non-invasive cardiac assessment
4. Heart ventricle diagnostics
5. Intraclass Correlation Coefficient in echocardiography

These five keywords have been chosen to optimize the visibility and reach of the article in search engines, targeting individuals and professionals interested in the latest advancements in cardiac imaging and right ventricular function assessment.