Product Introduction of Avastin 100mg Injection

Avastin 100mg Injection is a product of Roche, widely used as a part of anticancer therapy. It is primarily prescribed for the treatment of various types of cancers including colon or rectal, lung, kidney, breast, and ovarian cancers. The medication helps in slowing down the growth of cancer cells.

This injection might also be used to treat certain types of eye disease. It works by blocking the action of a protein called vascular endothelial growth factor (VEGF). By doing this, Avastin prevents growth of blood vessels, that cancer needs to continue growing.

Please keep in mind, this medication should always be administered by a healthcare professional and it is never meant for self-medication. The dose, duration, and method of administration for this drug is usually determined by the healthcare professional based on the disease condition, age, and response to the previous treatment.

Avastin may have certain side effects such as hypertension, fatigue, increased protein in urine, etc., so continuous monitoring is recommended during treatment. Always consult with medical professionals before starting or stopping the medication.

Uses of Avastin 100mg Injection

Avastin 100mg Injection is an anti-cancer medication. It is classified as a ‘monoclonal antibody’ that inhibits the growth and proliferation of cancerous cells. It is used to treat various types of cancers such as colon and rectum, lung, kidney, brain, ovarian and certain types of breast cancer.

The medication works by blocking a certain protein called vascular endothelial growth factor (VEGF) which promotes the growth of blood vessels that provide the cancer cells with the nutrients and oxygen they need to grow and multiply. By interfering with this process, Avastin can slow down or stop the growth of the cancer cells.

However, Avastin 100mg Injection can cause some side effects such as nosebleeds, high blood pressure, proteinuria, etc., and is not recommended for all patients, especially those with certain heart or lung conditions, among others. Always, it should be used under the supervision of a healthcare professional.

Moreover, Avastin is also used in combination with other drugs to treat certain eye diseases by preventing new blood vessels from growing and leaking in the eye, which might cause a loss of vision.

You should always consult your doctor or a healthcare professional before starting any medication.

Please note that this information may not cover all possible uses, precautions, side effects, drug interactions, or contraindications. Always consult your healthcare provider to ensure the information provided fits your personal medical needs.

Benefits of Avastin 100mg Injection

Avastin 100mg Injection (Bevacizumab) is a cancer medication used to treat certain types of cancer (such as colon, rectal, lung, breast, kidney, and ovarian cancer). It works by blocking the action of a substance in the body that can cause cancer cells to grow and divide. Here are some of the benefits:

1. Effective in Cancer Treatment: The injection effectively helps in slowing down the growth of new blood vessels and is very effective in the treatment of cancer.

2. Slows Cancer Spread: It can prevent the growth of tumors and halt the spread of cancerous cells around the body, making it easier for other cancer treatments such as chemotherapy to be more effective.

3. Prolongs Life: Studies show that Avastin can prolong the life of patients with certain types of advanced cancer.

4. Multifunctional: It can be used for the treatment of different types of cancers such as colorectal, lung, breast, glioblastomas, and kidney cancers.

5. Therapy Combination: It can be used in combination with other treatment regimens which contributes to a more effective treatment.

6. Reduces Symptoms: Avastin helps manage symptoms of the disease, improving the patient’s quality of life.

Please consult with your healthcare provider for comprehensive information, suitable dosage, possible side effects, and potential drug interactions before beginning treatment.

Side Effects of Avastin 100mg Injection

Avastin (bevacizumab) is a specially designed medication used to treat various types of cancer. However, like all medicines, it may have side effects in some patients. Here are some potential side effects associated with Avastin 100mg Injection:

1. Hypertension (high blood pressure)
2. Proteinuria (presence of abnormal quantities of protein in urine)
3. Neutropenia (a low amount of white blood cells in the blood, which can increase the risk of infection)
4. Vomiting
5. Fatigue
6. Back Pain
7. Headache
8. Taste changes
9. Decreased white blood cell count (leukopenia)
10. Nosebleeds
11. Skin rash
12. Dry or cracking skin
13. Weight Loss
14. Constipation
15. Joint pain
16. Diarrhea

In rare cases, Avastin can cause more serious side effects such as gastrointestinal perforation (a hole that develops in the wall of the gut), wound healing complications, hemorrhage (heavy bleeding), and pulmonary embolism (a blockage in the pulmonary artery).

Remember, this is not a complete list and others may occur. Please consult your healthcare professional for advice about side effects. Additionally, you should report to your doctor if these side effects become severe or do not go away.

How to Use Avastin 100mg Injection

Avastin (bevacizumab) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Avastin 100mg Injection is usually administered by a healthcare professional and is not meant for self-administration.

The procedure usually goes as follows:

1. Avastin is injected into a vein through an IV. A healthcare provider will administer the injection.

2. The injection is usually given once every 2 to 3 weeks.

3. Dosage is based on the patient’s medical condition, weight, and response to treatment.

This medication must be checked visually for particles or discoloration prior to administration. If either is present, do not use the liquid.

While using Avastin, you may need frequent blood tests and urine tests, and your blood pressure will also need to be checked often.

Side effects can include high blood pressure, nosebleeds, rectal bleeding, mouth sores, cough, voice changes, loss of appetite, diarrhoea, weight loss, headache, dizziness, dry skin, changes in the colour of your hair, or dry or watery eyes. Many more severe side effects can also occur.

Remember, this is a general guide. Always consult with your healthcare provider for accurate information.

Working Mechanism of Avastin 100mg Injection

Avastin, generically called bevacizumab, is a type of medication known as a monoclonal antibody, which is designed to recognize and attach to specific proteins in the body.

Here’s a general idea of how Avastin works:

1. Targeting Vascular Endothelial Growth Factor (VEGF): The primary target of Avastin is a protein called vascular endothelial growth factor, or VEGF. This protein plays a crucial role in the growth of blood vessels.

2. Inhibiting Blood Vessel Formation: Healthy cells create VEGF to produce new blood vessels during bodily functions like wound healing. However, cancerous cells misuse this protein to develop blood vessels for their nourishment and growth. By binding to VEGF, Avastin inhibits the process through which tumors form their blood supply (a process called angiogenesis).

3. Blocking Tumor Growth: When the tumor can’t generate new blood vessels, it lacks the nutrients and oxygen it requires to grow. Consequently, the tumor’s growth is stalled.

Please note that the action of Avastin does not eliminate the tumor but slows its growth. It is often used in combination with other cancer-fighting drugs for a more holistic treatment approach.

As an injection, Avastin is usually administered into a vein by a healthcare provider. The dosage and schedule depend on the patient’s medical condition, response to treatment, and the type of cancer being treated. It’s always crucial to have a healthcare professional supervise the process, and patients should consult their doctors or pharmacists before taking Avastin.

Safety Advice of Avastin 100mg Injection

Avastin (Bevacizumab) 100mg is a medication primarily used in the treatment of certain types of cancers. Here is some safety advice associated with its usage:

1. Always use Avastin 100mg under the utter supervision of a healthcare provider in a clinical setting as it is given by an intravenous injection.

2. Dosage and frequency should be strictly adhered to as prescribed by your healthcare provider. Overdosage can cause severe side effects.

3. It is necessary to conduct routine laboratory tests, including kidney and liver function tests, while taking this medication to check your response to therapy.

4. Avastin might have adverse effects on wound healing, particularly after surgery. Make sure to inform your doctor about any planned surgeries or recent ones.

5. This drug may increase the risk of severe gastrointestinal perforation, especially in patients with a history of inflammatory bowel disease or other gastrointestinal risk factors. Consult with your physician before starting therapy.

6. If you are pregnant or breastfeeding, consulting your healthcare provider before use is crucial. This treatment could harm an unborn baby or a nursing infant.

7. During the course of treatment, maintain good hydration to minimize kidney damage caused by the medicine.

8. This medicine should not be used in patients with hypersensitivity or allergy to Bevacizumab or any of its ingredients.

9. During the course and for a minimum of 6 months after your last dose of Avastin, use effective contraception if you or your partner could become pregnant.

Finally, bear in mind that individual responses to Avastin 100mg can vary considerably. Therefore, if you experience any side effects or discomfort after starting the medication, consult your healthcare provider immediately. This is not a complete list of safety advice. Always follow the specific instructions of your healthcare provider.

What if you forgot to take Avastin 100mg Injection

Avastin (Bevacizumab) is a medication typically used in the treatment of various cancers. It’s important to follow your doctor’s prescribed schedule for administering this medication. If you forget a dose:

1. Inform your healthcare provider immediately. They might provide instructions for when to take your next dose.

2. Don’t double up on your next dose to make up for the missed dose.

The regularity and timing of Avastin injections can be crucial in managing cancer, so consistently forgetting might result in decreased effectiveness of treatment.

Remember, each patient’s situation is unique, so always contact your healthcare provider for advice if you miss a dose. Do not rely on general advice, it’s always necessary to talk with your own doctor. Regular adherence to the dosing schedule is crucial to get the most benefit from the medication.

FAQ’s about Avastin 100mg Injection

Avastin 100mg Injection is a cancer medication used to treat specific types of cancers such as colon, rectum, lung, kidney, breast, and others.

Question: What is Avastin 100mg Injection?
Answer: Avastin (bevacizumab) 100mg is an anti-cancer drug used to control the growth and spread of cancer cells in the body.

Question: How does Avastin 100mg Injection work?
Answer: Avastin works by inhibiting the blood supply that helps the tumor to grow and spread. It specifically inhibits a substance called vascular endothelial growth factor (VEGF) which assists the tumor to grow blood vessels.

Question: How should this medicine be taken?
Answer: It is administered by a healthcare provider in a clinical setting. However, the dosage can varry depending on the patient’s health condition and the type of cancer being treated.

Question: What are the side effects of the Avastin 100mg Injection?
Answer: There can be side effects such as high blood pressure, bleeding, delayed wound healing, diarrhea, decreased white blood cell count, fatigue, and loss of appetite. If you encounter serious side effects, immediately seek medical help.

Question: Who should not use Avastin 100mg Injection?
Answer: Pregnant or breastfeeding women should not use Avastin due to potential risk to the fetus or the newborn. Likewise, it should not be used if you have hypersensitivity to bevacizumab, proteinuria, uncontrolled hypertension, or recent surgery.

Question: How long should I use Avastin 100mg Injection?
Answer: The duration of the therapy should be determined by your doctor, based on your type of cancer and response to treatment.

Please note this is a general FAQ. Always consult with a healthcare provider for advice pertaining to your specific circumstance.

And List out Possible research or clinical trails References about Avastin 100mg Injection

Avastin is a prescription drug manufactured by the Swiss multinational healthcare company Roche. Its generic name is Bevacizumab and it belongs to the class of drugs known as angiogenesis inhibitors, used to treat various forms of cancer, including colorectal, lung, breast, kidney, brain, and ovarian cancers.

Avastin works by blocking a certain protein (VEGF) in the body which helps cancers to grow and spread by increasing the growth of new blood vessels.

Research and Clinical Trials References:

1. A Study of Avastin (Bevacizumab) in Combination With Xeloda (Capecitabine) in Patients With Metastatic Breast Cancer. (AVADO) (2007) – Identifier: NCT00333775.

2. First-Line Treatment of Patients With Metastatic Colorectal Cancer With FOLFOX4 and Avastin (2005) – Identifier: NCT00109070.

4. Bevacizumab in treating patients with Recurrent Glioblastoma Multiforme (2010) – Identifier:NCT00884741.

5. Evaluation of continued Avastin via intravenous use in colorectal cancer treatment (2013) – Identifier: NCT01765582.

6. Randomized Study of Combination Chemotherapy With Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (EPOCH) With Rituximab (Rituxan) and Bevacizumab (Avastin) Versus EPOCH-R in Patients With Previously Untreated Diffuse Large B-Cell Non-Hodgkin’s Lymphoma – Identifier: NCT00118209.

Please consult with your healthcare provider for more detailed information and recommend the most appropriate and beneficial treatments.

Facts about Avastin 100mg Injection

Avastin, generically known as bevacizumab, is a medication often used in the treatment of several different types of cancer. Here are some key facts on Avastin 100mg injection:

1. Usage: Avastin is used to treat types of cancer such as colorectal, lung, breast, kidney, cervical, and ovarian cancers.

2. Mechanism: It works by interfering with the growth and spread of cancer cells within the body. Specifically, it prevents the growth of blood vessels that feed tumors, thereby starving them of nutrients they need to grow.

3. Administration: It is given as an infusion into a vein, usually administered every 2 to 3 weeks.

4. Side Effects: Like most medicines, Avastin comes with possible side effects. These can include high blood pressure, tiredness, loss of appetite, changes in taste, dry skin, bleeding, and increased protein in urine. More serious side effects can occur, including heart problems, open wounds that won’t heal, bleeding in the lungs, and severe bleeding in the stomach or intestines.

5. Precaution: Prior to using Avastin, it is important to inform your doctor about any pre-existing conditions, allergies or current medications. People with heart problems, high blood pressure, kidney diseases, or recent surgery may need closer monitoring.

6. Pregnancy and Breastfeeding: It is not recommended for use during pregnancy or while breastfeeding due to potential harm to the baby.

7. Interaction with Other Drugs: Bevacizumab can interact with certain other medications, so it’s crucial to keep your doctor informed about all medicines, supplements, or vitamins you are currently taking.

As with any medication, it’s advisable to discuss with your doctor or healthcare professional about the risks and benefits before starting the treatment.

All substitutes in USA and India of Avastin 100mg Injection

Avastin 100mg Injection is prescribed for treating various types of cancers. It is a brand of the drug called Bevacizumab. Here are some substitutes available in the USA and India:

In the USA:
1. Mvasi: This is another brand name for Bevacizumab manufactured by Amgen Inc.
2. Zirabev: Zirabev, also a Bevacizumab, is produced by Pfizer Inc.

In India:
1. BevaciRel: A generic version of Bevacizumab manufactured by Reliance Life Science.
2. Avestinova: Marketed by Zuventus Healthcare Ltd.
3. Bevatas: Produced by Intas pharmaceuticals Ltd.
4. Bevacirel: Manufactured by Reliance Life Sciences Pvt Ltd.
5. Bivac: Manufactured by BDR Pharmaceuticals International Pvt Ltd.

The drugs listed above are not the only alternatives, others may be available based on availability and approval in these countries. Also, please note that though these drugs have the same composition, their efficacy may differ. Always consult with a healthcare professional before switching medication.


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Last Update: December 3, 2023